Gossypol inhibits phosphorylation of Bcl-2 in human leukemia HL-60 cells.

@article{Huang2010GossypolIP,
  title={Gossypol inhibits phosphorylation of Bcl-2 in human leukemia HL-60 cells.},
  author={Li-heng Huang and Jia-qi Hu and Wei-qun Tao and Yuan-hong Li and Guan-ming Li and Pei-yi Xie and Xiao-shan Liu and Jikai Jiang},
  journal={European journal of pharmacology},
  year={2010},
  volume={645 1-3},
  pages={
          9-13
        }
}
Gossypol is an attractive therapeutic anti-tumor agent as an apoptosis inducer and is being evaluated in preclinical tests. However, the molecular mechanisms underlying apoptosis induction by gossypol in malignant cells have not been completely enunciated. Here we investigate the alterations of Bcl-2/Bcl-xL/Mcl-1 protein levels and Bcl-2 phosphorylation in gossypol-induced apoptosis in human leukemia HL-60 cells. We found that gossypol treatment inhibited cell growth and induced apoptosis in HL… CONTINUE READING
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