Gossypol induces apoptosis in multiple myeloma cells by inhibition of interleukin-6 signaling and Bcl-2/Mcl-1 pathway

@inproceedings{Sadahira2014GossypolIA,
  title={Gossypol induces apoptosis in multiple myeloma cells by inhibition of interleukin-6 signaling and Bcl-2/Mcl-1 pathway},
  author={Ken Sadahira and M Sagawa and Tomonori Nakazato and Hideo Uchida and Yasuo Ikeda and Shinichiro Okamoto and Hideaki Nakajima and Masahiro Kizaki},
  booktitle={International journal of oncology},
  year={2014}
}
Multiple myeloma (MM) is a clonal plasma cell disorder affecting the immune system with various systemic symptoms. MM remains incurable even with high dose chemotherapy using conventional drugs, thus necessitating development of novel therapeutic strategies. Gossypol (Gos) is a natural polyphenolic compound extracted from cotton plants, and has been shown to possess anti-neoplastic activity against various tumors. Recent studies have shown that Gos is an inhibitor for Bcl-2 or Bcl-XL acting as… CONTINUE READING

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