Gossypol induces apoptosis in human PC-3 prostate cancer cells by modulating caspase-dependent and caspase-independent cell death pathways.

@article{Zhang2007GossypolIA,
  title={Gossypol induces apoptosis in human PC-3 prostate cancer cells by modulating caspase-dependent and caspase-independent cell death pathways.},
  author={Manchao Zhang and Hongpeng Liu and Zhenkun Tian and Brian N. Griffith and Min Ji and Qingdi Quentin Li},
  journal={Life sciences},
  year={2007},
  volume={80 8},
  pages={767-74}
}
The rate of gossypol-induced apoptosis does not correlate very well with the same dose of gossypol-induced cell growth inhibition, indicating an anti-proliferative effect of gossypol. Using a co-immunoprecipitation assay, it was observed that the level of Bcl-X(L) protein bound to Bax was clearly lower than that of Bcl-2 protein at 5 micro M of gossypol treatment, and the level of Bim protein bound to Bcl-X(L) was lowered at 20 micro M of gossypol treatment for 24 h, implicating that gossypol… CONTINUE READING

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