Goosecoid and HNF-3beta genetically interact to regulate neural tube patterning during mouse embryogenesis.

@article{Filosa1997GoosecoidAH,
  title={Goosecoid and HNF-3beta genetically interact to regulate neural tube patterning during mouse embryogenesis.},
  author={Stefania Filosa and Jaime A Rivera-P{\'e}rez and A P G{\'o}mez and Anne Gansmuller and Hiroshi Sasaki and Richard R. Behringer and Sharyn L Ang},
  journal={Development},
  year={1997},
  volume={124 14},
  pages={2843-54}
}
The homeobox gene goosecoid (gsc) and the winged-helix gene Hepatic Nuclear Factor-3beta (HNF-3beta) are co-expressed in all three germ layers in the anterior primitive streak and at the rostral end of mouse embryos during gastrulation. In this paper, we have tested the possibility of functional synergism or redundancy between these two genes during embryogenesis by generating double-mutant mice for gsc and HNF-3beta. Double-mutant embryos of genotype gsc(-/-);HNF-3beta(+/-) show a new… CONTINUE READING
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