History of Pathology Dr Goodpasture: "I was not aware of such a connection between lung and kidney disease"
This article describes how Dr Ernest Goodpasture's 1919 study of influenza became the basis for his name being attached to pulmonary-renal syndromes by Stanton and Tange in 1958. Dr Goodpasture was…
Goodpasture's autoimmune disease - A collagen IV disorder.
- Medicine, BiologyMatrix biology : journal of the International Society for Matrix Biology
- Medicine, Biology
Goodpasture's disease is characterized by the association of pulmonary hemorrhage, extracapillary glomerulonephritis, and anti-glomerular basement membrane antibodies, due to autoantibodies against the NC1 domain of the alpha3 chain of type IV collagen.
Goodpasture's Syndrome With Negative Serology
This case illustrates the classic clinical features of the pulmonary manifestations of anti-GBM disease with negative serological markers confirmed by immunofluorescence of alveolar basement membrane sampled at autopsy.
[Goodpasture's syndrome with neurologic involvement and negative ANCA].
- Medicine, BiologyNefrologia : publicacion oficial de la Sociedad Espanola Nefrologia
The case of a 20-year-old man with RPGN accompanied by bloody sputum, tonic-clonic seizure and high titers of anti-GBM antibody, who underwent deceased-donor renal transplantation and is now in remission.
Characteristics and outcome of Goodpasture’s disease in children
- Medicine, BiologyClinical Rheumatology
The case of a 14-year-old girl with primary pulmonary symptoms diagnosed with aGD is described, the fourth child that presented with only pulmonary symptoms and no or minimal renal involvement, and no case was identified with signs of relapse after remission.
Dr Goodpasture: "I was not aware of such a connection between lung and kidney disease".
- MedicineAnnals of diagnostic pathology
Goodpasture’s or Anti-glomerular Basement Membrane (GBM) Disease
- Medicine, Biology
Goodpasture’s disease is the term for a pulmonary-renal syndrome associated with rapidly progressive glomerulonephritis* and anti-glomerular basement (GBM) membrane antibodies and is used alongside…
Goodpasture's disease: a report of ten cases and a review of the literature.
- Medicine, BiologyAutoimmunity reviews
SHOWING 1-10 OF 11 REFERENCES
Recurrent Goodpasture's disease.
- MedicineAmerican journal of kidney diseases : the official journal of the National Kidney Foundation
Long-Term Outcome of AntiGlomerular Basement Membrane Antibody Disease Treated with Plasma Exchange and Immunosuppression
- Medicine, BiologyAnnals of Internal Medicine
The long-term outcome in a large cohort of patients with anti-GBM antibody disease who were treated uniformly with intensive immunosuppression and plasma exchange is established and the extent of recovery from severe renal failure is documented.
THE SIGNIFICANCE OF CERTAIN PULMONARY LESIONS IN RELATION TO THE ETIOLOGY OF INFLUENZA
I am convinced that there existed a primary pneumonia produced by the poison of influenza, and from a study of the material which I have had available from the height of the epidemic last fall and subsequently I is convinced that this is true and that the etiological factor is not any one of the numerous pathogenic microörganisms which have been cultivated from the lungs, but an unknown virus which produces the general intoxication and may produce characteristic lesions in the lungs with or without the coincidence of other infections agents.
THE ROLE OF ANTI-GLOMERULAR BASEMENT MEMBRANE ANTIBODY IN THE PATHOGENESIS OF HUMAN GLOMERULONEPHRITIS
- Medicine, BiologyThe Journal of experimental medicine
It appears that patients forming anti-GBM antibodies may not be good candidates for renal transplantation since they are likely to produce in the transplants the nephritic changes already suffered by their own kidneys.
Molecular cloning of the human Goodpasture antigen demonstrates it to be the alpha 3 chain of type IV collagen.
- BiologyThe Journal of clinical investigation
To characterize the autoantigen of Goodpasture's disease, a molecule of 26-kD reactive with autoantibodies from patients' sera was purified from collagenase digests of sheep glomerular basement membrane and confirmed to be the alpha 3 chain of type IV collagen.
Immune Aspects of the Glomerulonephritis Associated with Pulmonary Hemmorhage
- Medicine, Biology
Excerpt The simultaneous appearance of pulmonary hemorrhage and an acute glomerulonephritis has been observed often enough to warrant the conclusion that this represents a distinct clinical entity ...
Anti-glomerular basement membrane antibody-induced glomerulonephritis.
- MedicineKidney international
Transplantation was usually successful when delayed until circulating antiGBM antibodies had declined; however, evidence of recurrent glomerulonephritis developed in 19, possibly 20, of 34 transplanted patients, resulting in graft failure in seven, possibly eight, instances.
Susceptibility to anti-glomerular basement membrane disease is strongly associated with HLA-DRB1 genes.
- Biology, MedicineKidney international
Analysis of inherited haplotypes provided further evidence that the primary association was with genes at the DRB1 locus, and supports the hypothesis that the HLA associations in anti-GBM disease reflect the ability of certain Class II molecules to bind and present peptides derived from the autoantigen to T helper cells.
Goodpasture's syndrome (pulmonary haemorrhage associated with glomerulonephritis).
- MedicineAustralasian annals of medicine