Good vibrations in enzyme-catalysed reactions.

@article{Hay2012GoodVI,
  title={Good vibrations in enzyme-catalysed reactions.},
  author={Sam Hay and Nigel S. Scrutton},
  journal={Nature chemistry},
  year={2012},
  volume={4 3},
  pages={
          161-8
        }
}
Fast motions (femtosecond to picosecond) and their potential involvement during enzyme-catalysed reactions have ignited considerable interest in recent years. Their influence on reaction chemistry has been inferred indirectly from studies of the anomalous temperature dependence of kinetic isotope effects and computational simulations. But can such motion reduce the width and height of energy barriers along the reaction coordinate, and contribute to quantum mechanical and/or classical nuclear… CONTINUE READING
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Publications referenced by this paper.
SHOWING 1-10 OF 74 REFERENCES

Dynamics and dissipation in enzyme catalysis.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2011

Temperature dependence of the kinetic isotope effects in thymidylate synthase

N Kanaan
  • A theoretical study. J. Am. Chem. Soc. 133,
  • 2011

Temperature dependence of the kinetic isotope effects in thymidylate synthase . A theoretical study

E. Hatcher, A. Soudackov, S. Hammes-Schiffer
  • J . Am . Chem . Soc .
  • 2011

Characterizing the dynamics of functionally relevant complexes of formate dehydrogenase.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2010

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