Good tolerability of high dose colistin-based therapy in patients with haematological malignancies.


PURPOSE Colistin is usually the only drug fully active against multi-drug resistant Gram-negative bacteria, but its nephrotoxicity might limit its use. Recent pharmacokinetic/pharmacodynamic data suggest that high dose of colistin, preceded by a loading dose, are needed to maximize its antibacterial effect. The aim of this study was to determine the safety… (More)
DOI: 10.1007/s15010-017-1010-7