Good clinical outcomes but high rates of adverse reactions during linezolid therapy for serious infections: a proposed protocol for monitoring therapy in complex patients.

Abstract

We assessed the toxicity and clinical outcomes associated with linezolid therapy (mean duration, 29+/-28 days; range, 8 to 185 days) in 44 patients with serious gram-positive infections. Although a clinical cure was achieved in 73% of the cases, 28/44 (64%) had adverse reactions (thrombocytopenia, n=13; anemia, n=7; gastrointestinal, n=12; peripheral neuropathy, n=1; serotonin syndrome, n=1), such that a systematic monitoring protocol was developed.

Cite this paper

@article{Bishop2006GoodCO, title={Good clinical outcomes but high rates of adverse reactions during linezolid therapy for serious infections: a proposed protocol for monitoring therapy in complex patients.}, author={Emma J Bishop and Sharmila Melvani and Benjamin P. Howden and Patrick G. P. Charles and M. Lindsay Grayson}, journal={Antimicrobial agents and chemotherapy}, year={2006}, volume={50 4}, pages={1599-602} }