Good bye "lactic acid"; hello lactate and acid.

@article{Prakash2008GoodB,
  title={Good bye "lactic acid"; hello lactate and acid.},
  author={E. Prakash},
  journal={Journal of applied physiology},
  year={2008},
  volume={105 1},
  pages={
          363
        }
}
  • E. Prakash
  • Published 2008
  • Chemistry, Medicine
  • Journal of applied physiology
TO THE EDITOR: I benefited from reading this Point:Counterpoint discussion (2, 3) and some of the papers cited therein and was shocked to learn that the construct of “lactic acidosis” has been questioned before (4). However, it is clear (from Ref. 1) that the reduction of pyruvate to lactate consumes two protons, and as Robergs et al. (4) have said, the production of lactate retards the development of acidosis and is definitely not the cause of it. My renewed understanding is that the proximate… Expand
The Use of Lactate as a Biomarker
TLDR
The term and concept of ‘‘lactic acidosis’’ should be rejected as the construct is not biochemically valid, and a new approach to lactate accumulation based on precellular, cellular, and postcellular mechanisms is proposed. Expand
Clinical use of plasma lactate concentration. Part 1: Physiology, pathophysiology, and measurement
OBJECTIVE To review the current literature with respect to the physiology, pathophysiology, and measurement of lactate. DATA SOURCES Data were sourced from veterinary and human clinical trials,Expand
The workload and plasma ion concentration in a training match session of high-goal (elite) polo ponies.
TLDR
This study indicates that the horses participating in a training match underwent a high-intensity effort with alterations in electrolytes and acid-base equilibrium, which should be carefully conducted, with a suitable recovery period before the main match. Expand
Bicarbonate ingestion has no ergogenic effect on consecutive all out sprint tests in BMX elite cyclists
TLDR
Sodium bicarbonate ingestion modified significantly the blood acid–base balance, although the induced alkalosis did not improve the Wingate test performance, RPE and perceived readiness across three consecutive WTs in elite BMX cyclists. Expand

References

SHOWING 1-5 OF 5 REFERENCES
Causes of differences in exercise-induced changes of base excess and blood lactate
TLDR
Neither the use of ΔABE nor of ΔSBE provides evidence for differences in H+ and La− transport across tissue cell membranes, when performing correct comparisons and considering Cl−/HCO3− exchange between erythrocytes and extracellular fluid. Expand
A CRITIQUE OF THE PARAMETERS USED IN THE EVALUATION OF ACID-BASE DISORDERS ???WHOLE-BLOOD BUFFER BASE??? AND ???STANDARD BICARBONATE??? COMPARED WITH BLOOD pH AND PLASMA BICARBONATE CONCENTRATION
TLDR
The degree and direction of primary respiratory disturbances can be evaluated by the determination of carbon dioxide tension (pCO2) in the blood, since this quantity is directly proportional to the actual amount of dissolved carbonic acid. Expand
Counterpoint: Lactic acid is not the only physicochemical contributor to the acidosis of exercise.
to the editor: The acidification of blood during muscular exercise cannot be understood from an analysis of blood from a single site, nor from examination of only arterial (or arterialized) blood.Expand
Last word on point:counterpoint: lactic acid is/is not the only physicochemical contributor to the acidosis of exercise.
TLDR
It is somewhat amusing that the acid base literature, beginning with Van Slyke, is studied according to Lindinger and Lindinger, while the counterpoint supporters often present only statements. Expand
THE GREAT TRANS-ATLANTIC ACID-BASE DEBATE.
TLDR
The approach to evaluation of acid-base disorders used in this on-line text is known as the Boston approach and an alternative method of evaluation promoted by Astrup and Siggaard-Anderson from Copenhagen uses the Base Excess approach. Expand