Gonocytes in testes of neonatal rats express the c-kit gene.

  title={Gonocytes in testes of neonatal rats express the c-kit gene.},
  author={Joanne M Orth and William Jester and Jingxin Qiu},
  journal={Molecular reproduction and development},
  volume={45 2},
Information gathered from mutant mouse models and from studies on normal puberal and adult animals points to the product of the c-kit gene, a tyrosine kinase surface receptor, and the kit-ligand (KL) as important for gametogenesis in males. In fetuses, KL serves as a survival factor for primordial germ cells, at least in vitro, and in adults activity of the c-kit gene has been indirectly related to survival and subsequent development of differentiating spermatogonia. However, because of the… CONTINUE READING
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