Gonococcal lipooligosaccharide sialylation prevents complement-dependent killing by immune sera.

@article{Wetzler1992GonococcalLS,
  title={Gonococcal lipooligosaccharide sialylation prevents complement-dependent killing by immune sera.},
  author={Lee M. Wetzler and Kerrie Barry and Milan S. Blake and Emil C. Gotschlich},
  journal={Infection and immunity},
  year={1992},
  volume={60 1},
  pages={39-43}
}
Previous investigators have demonstrated that a sialic acid residue is added to the terminal galactose moiety of gonococcal lipooligosaccharide (LOS) when incubated with 5'-CMP-N-acetylneuraminic acid. When this in vitro sialylation occurs, gonococci become resistant to the bactericidal activity of normal human serum. This is believed to result because the added sialic acid residue blocks the binding of bactericidal anti-LOS antibodies present in normal human serum. We extend these studies by… CONTINUE READING

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White blood cells including polymorphonuclear phagocytes contain a factor which induces gonococcal resistance to complement - mediated serum killing

P. V. Patel, D. R. Veale, +3 authors H. Smith
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