Gonadotropin therapy failure secondary to human chorionic gonadotropin-induced antibodies.

@article{Sokol1981GonadotropinTF,
  title={Gonadotropin therapy failure secondary to human chorionic gonadotropin-induced antibodies.},
  author={Rebecca Z. Sokol and R. D. Mcclure and Michael Peterson and Ronald S. Swerdloff},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1981},
  volume={52 5},
  pages={929-32}
}
A 15-yr-old male with the diagnosis of Kallmann's syndrome manifested secondary gonadal resistance during a third treatment course of hCG. A serum sample obtained 6 months after failure of the patient to respond to hCG bound [125I]hCG 60% at a 1:2 dilution of serum; 50% at 1.5; 28% at 1:50; 21% at 1:100; and less than 5% at a 1:500 dilution. Serial sampling of the patient's serum over a 22-month period demonstrated a progressive decline in binding capacity, decreasing to 32% binding of [125I… CONTINUE READING

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