Gonadotropin suppression of apoptosis in cultured preovulatory follicles: mediatory role of endogenous insulin-like growth factor I.

@article{Chun1994GonadotropinSO,
  title={Gonadotropin suppression of apoptosis in cultured preovulatory follicles: mediatory role of endogenous insulin-like growth factor I.},
  author={S Y Chun and H{\aa}kan Billig and Jonathan L. Tilly and Isao Furuta and Alex Tsafriri and Aaron J Hsueh},
  journal={Endocrinology},
  year={1994},
  volume={135 5},
  pages={1845-53}
}
Although the majority of ovarian follicles undergo atresia through a mechanism involving apoptotic cell death, in vivo studies concerning the hormonal regulation of atresia have been difficult due to the presence of heterogeneous population of follicles in the ovary. In the present study, the regulation of follicle apoptosis by gonadotropins, insulin-like growth factor I (IGF-I), and IGF-binding protein 3 (IGFBP-3) was examined using a serum-free culture of preovulatory follicles. Immature rats… CONTINUE READING
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