Gonadotropin-releasing hormone-regulated prohibitin mediates apoptosis of the gonadotrope cells.

@article{Savulescu2013GonadotropinreleasingHP,
  title={Gonadotropin-releasing hormone-regulated prohibitin mediates apoptosis of the gonadotrope cells.},
  author={Dana Savulescu and Jiajun Feng and Yueh Shyang Ping and Oliver Mai and Ulrich Boehm and Bin He and Bert W O'malley and Philippa Melamed},
  journal={Molecular endocrinology},
  year={2013},
  volume={27 11},
  pages={1856-70}
}
GnRH regulates circulating levels of the gonadotropins but has also been implicated in establishing the gonadotrope cell population. Consistent with this, GnRH induces proliferation of partially differentiated gonadotropes, while reducing the numbers of fully differentiated cells. We have previously reported that the proapoptotic protein, prohibitin (PHB) is expressed more abundantly in gonadotrope-derived LβT2 cells than in partially differentiated αT3-1 gonadotrope precursor cells, suggesting… CONTINUE READING