Gonadotropin-releasing hormone neurosecretion in the human hypothalamus: in vitro regulation by dopamine.

@article{Rasmussen1986GonadotropinreleasingHN,
  title={Gonadotropin-releasing hormone neurosecretion in the human hypothalamus: in vitro regulation by dopamine.},
  author={Dennis Rasmussen and James H. Liu and Paul L. Wolf and Samuel Yen},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1986},
  volume={62 3},
  pages={479-83}
}
An in vitro perifusion system was used to investigate GnRH release from adult human hypothalami in response to dopamine (DA) and the DA receptor antagonist haloperidol (HAL). Administration of a 1-microM pulse of DA consistently elicited a mean +/- SE 218 +/- 59% increase (P less than 0.05; n = 5) in GnRH release, whereas 1 microM HAL had no effect. Administration of 1 microM DA during three perifusions in which 1 microM HAL was added to the medium failed to alter basal GnRH release. In… CONTINUE READING