Gonadotropin-releasing hormone-induced stimulation of the rat secretogranin II promoter involves activation of CREB.

@article{Song2003GonadotropinreleasingHS,
  title={Gonadotropin-releasing hormone-induced stimulation of the rat secretogranin II promoter involves activation of CREB.},
  author={Seok Bean Song and Myungchull Rhee and Mark S Roberson and Richard A. Maurer and Kyoon Eon Kim},
  journal={Molecular and cellular endocrinology},
  year={2003},
  volume={199 1-2},
  pages={29-36}
}
To investigate the events involved in regulation of the secretogranin II (SgII) gene, luciferase reporter constructs were transfected into gonadotrope-derived, alphaT3-1 cells. DNA between -91 and -60 relative to the transcription start site was found to be required for GnRH induced SgII reporter gene activation. This region contains a consensus cAMP… CONTINUE READING