Gonadotropin-releasing hormone attenuates pregnancy-associated thymic involution and modulates the expression of antiproliferative gene product prohibitin.

@article{Dixit2003GonadotropinreleasingHA,
  title={Gonadotropin-releasing hormone attenuates pregnancy-associated thymic involution and modulates the expression of antiproliferative gene product prohibitin.},
  author={Vishwa Deep Dixit and Rajagopala Sridaran and Megan A Edmonsond and Dennis Taub and Winston E. Thompson},
  journal={Endocrinology},
  year={2003},
  volume={144 4},
  pages={1496-505}
}
Thymic involution during pregnancy is believed to be a critical adaptive mechanism for regulation and control of the maternal immune system. These regulatory feedback mechanisms are important for the survival of the semiallogeneic fetus. In the present study, we examined the effects of GnRH on pregnancy-induced thymic involution by characterizing the expression patterns of prohibitin (PHB), an antiproliferative gene product, GnRH, and GnRH receptor (GnRH-R) proteins in the rat thymus and in… CONTINUE READING