Gonadotropin-releasing hormone and gonadotropin-releasing hormone receptor messenger ribonucleic acids expression in nontumorous and neoplastic pituitaries.

@article{Sanno1997GonadotropinreleasingHA,
  title={Gonadotropin-releasing hormone and gonadotropin-releasing hormone receptor messenger ribonucleic acids expression in nontumorous and neoplastic pituitaries.},
  author={Naoko Sanno and Long Jin and Xiang zhong Qian and Robert Yoshiyuki Osamura and Bernd Walter Scheithauer and K{\'a}lm{\'a}n Kov{\'a}cs and Ricardo Vincent Lloyd},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1997},
  volume={82 6},
  pages={
          1974-82
        }
}
In the nontumorous pituitary, GnRH stimulates the release and synthesis of LH and FSH by gonadotroph cells via the GnRH receptor (GnRH-R). Little is known, however, about expression of GnRH and GnRH-R messenger RNAs (mRNAs) in nontumorous pituitary tissue and in adenomas. To learn more about the distribution and regulatory roles of GnRH and its receptor, we investigated the expression of both GnRH and GnRH-R mRNAs in nontumorous human pituitary and in various types of pituitary adenomas using… CONTINUE READING
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