Gonadotropin-releasing hormone analogues for palliation of carcinoma of the prostate

@article{Wenderoth1983GonadotropinreleasingHA,
  title={Gonadotropin-releasing hormone analogues for palliation of carcinoma of the prostate},
  author={Ulrich K. Wenderoth and G{\"u}nther H. Jacobi},
  journal={World Journal of Urology},
  year={1983},
  volume={1},
  pages={40-48}
}
SummarySince the introduction of contrasexual treatment as the basic concept of palliation of prostatic carcinoma in the 1940's, orchiectomy, estrogens, and, in recent years, antiandrogens have become generally accepted treatment forms. Three facts: 1) estrogen treatment being at best palliative and at worst dangerous; 2) surgical castration having psychological impacts, at least in the younger age group; and 3) both being probably ineffective from the beginning, have led us to investigate an… 
10 Citations

Buserelin in the treatment of prostatic cancer.

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  • Medicine, Biology
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
  • 1989

Treatment of prostatic cancer with a gonadotropin-releasing hormone agonist analog: acute and long term effects on endocrine functions of testis tissue.

The elevation in serum PAP at the beginning of the agonist treatment and the small residual testicular T production after 6 months may not be clinically important, however, they indicate the necessity of comparative long term studies between orchiectomy and GnRH agonists in the treatment of patients with prostatic cancer.

Surgical versus Medical Castration in the Management of Advanced Prostate Cancer

It is observed that, following orchidectomy, patients with advanced prostatic cancer experience relief of pain associated with calcification of lytic bone metastases and a fall in pre-treatment elevated acid phosphatase levels, and the administration of exogenous testosterone caused a return of symptoms.

Is disease flare a problem?

No distinctions have been made between clinical flare, with its manifestations of subjective or objective aggravation of cancer related symptoms, and the biochemical flare that results of the LHRH analog administration and that occurs in a majority of patients and is characterized by increases in testosterone, prostatic acid phosphatase, and prostate specific antigen.

Treatment of prostatic cancer. Newer forms of androgen deprivation.

Encouraging the initiation of androgen deprivation for patients with regional or distant metastases will improve the patient's course and attempts to provide a more complete androgen blockade hold the hope of delaying or preventing relapse, which usually occurs with continued androgens deprivation.

Orchidectomy or LHRH-analogue? Which do the patients prefer and what treatment would Norwegian urologists prefer if they had advanced cancer of the prostate?

A prospective study about whether patients prefer orchidectomy or medical castration with luteinising hormone releasing hormone analogues for the treatment of prostatic cancer found that most patients and urologists favoured medicalCastration.

Die Therapie des fortgeschrittenen Prostatakarzinoms mit Buserelin-Implantat

Erstmals sollte nun ein neu entwickeltes Depot-Praparat1 nach subcutaner Implantation auf Gleichmasigkeit der Buserelin-Abgabe und Kontinuitat der Testosteronsuppression bei Patienten mit fortgeschrittenem Prostatakarzinom (PCA) uberpruft werden.

La Terapia Ormonale Nel Cancro Della Prostata: Stato Attuale E Prospettive

II cancro della prostata e la neoplasia urologica pili frequente nell'anziano. Nel nostro paese esso rappresenta la terza causa di morte per neoplasia nel maschio, con circa 4.500 decessi all'anno*.

References

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Hoe 766, is a valuable alternative to conventional contrasexual measures for prostate cancer palliation and to improve the patient's compliance, however, the smallest single pernasal dosage effective for maintenance of down-regulation and steroidogenic arrest has still to be determined.

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For the past eight years the physician has been confronted with problems concerning the selection of the form of endocrine modification most efficacious for the particular needs of the patient, the designation of the most opportune time to institute therapy and the choice of secondary therapy once relapse has occurred.

Luteinizing hormone-releasing hormone does not inhibit testosterone production in rat interstitial cells in vitro.

In vitro testosterone production in response to 1--5 mIU human menopausal gonadotropin was markedly impaired in cells from rats treated with LHRHa for 2 days or longer and in rats treatedwith LHRH longer than 3 days, but the data do not, however, rule out a direct effect of L HRH or LHR Ha on testicular systems other than those involved in steroidogenesis.

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