Gonadotropin-releasing hormone analogue conjugates with strong selective antitumor activity.

  title={Gonadotropin-releasing hormone analogue conjugates with strong selective antitumor activity.},
  author={Istv{\'a}n P{\'a}lyi and Borb{\'a}la Vincze and S{\'a}ndor Lovas and Imre Mez{\"o} and J{\'a}nos Pat{\'o} and Adrienn K{\'a}lnay and Gizella Turi and Dezső Ga{\'a}l and R. M. Mihalik and Isabelle Peter and Istv{\'a}n Tepl{\'a}n and Richard F. Murphy},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={96 5},
Conjugation of gonadotropin-releasing hormone (GnRH) analogues GnRH-III, MI-1544, and MI-1892 through lysyl side chains and a tetrapeptide spacer, Gly-Phe-Leu-Gly (X) to a copolymer, poly(N-vinylpyrrolidone-co-maleic acid) (P) caused increased antiproliferative activity toward MCF-7 and MDA-MB-231 breast, PC3 and LNCaP prostate, and Ishikawa endometrial cancer cell lines in culture and against tumor development by xenografts of the breast cancer cells in immunodeficient mice. MCF-7 cells… CONTINUE READING
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