Gonadotropin-releasing hormone agonists suppress melanoma cell motility and invasiveness through the inhibition of alpha3 integrin and MMP-2 expression and activity.

@article{Moretti2008GonadotropinreleasingHA,
  title={Gonadotropin-releasing hormone agonists suppress melanoma cell motility and invasiveness through the inhibition of alpha3 integrin and MMP-2 expression and activity.},
  author={Roberta Manuela Moretti and Marina Montagnani Marelli and Stefania Mai and Patrizia Limonta},
  journal={International journal of oncology},
  year={2008},
  volume={33 2},
  pages={405-13}
}
Cutaneous melanoma represents the leading cause of skin cancer deaths. The prognosis of highly aggressive, metastatic melanoma is still very poor, due to the resistance of the disseminated tumor to existing therapies. The clarification of the molecular mechanisms regulating melanoma growth and progression might help identify novel molecular targets for the development of new therapeutic interventions. We previously showed that gonadotropin-releasing hormone (GnRH) receptors are expressed in… CONTINUE READING