Gonadotropin-releasing hormone agonist blocks anxiogenic-like and depressant-like effect of corticotrophin-releasing hormone in mice

@article{Umathe2008GonadotropinreleasingHA,
  title={Gonadotropin-releasing hormone agonist blocks anxiogenic-like and depressant-like effect of corticotrophin-releasing hormone in mice},
  author={Sudhir Niranjanrao Umathe and Pravinkumar Satyanarayan Bhutada and Nishant S. Jain and Nilima Shukla and Pankaj V. Dixit},
  journal={Neuropeptides},
  year={2008},
  volume={42},
  pages={399-410}
}
Corticotrophin-releasing factor (CRF) is reported to inhibit the release of gonadotropin-releasing hormone (GnRH). In addition to the endocrine effects, GnRH is reported to influence the behavior via its neuronal interactions. We therefore, hypothesized that anxiety and depression produced by CRF could be also subsequent to the decrease in GnRH. To support such possibility, we investigated the influence of GnRH agonists on CRF or CRF antagonist induced changes in social interaction time in… CONTINUE READING
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