Gonadotropin-releasing hormone (GnRH) receptors in tumors: a new rationale for the therapeutical application of GnRH analogs in cancer patients?

@article{Marelli2006GonadotropinreleasingH,
  title={Gonadotropin-releasing hormone (GnRH) receptors in tumors: a new rationale for the therapeutical application of GnRH analogs in cancer patients?},
  author={Marina Montagnani Marelli and Roberta Manuela Moretti and Joanna Januszkiewicz-Caulier and Marcella Motta and Patrizia Limonta},
  journal={Current cancer drug targets},
  year={2006},
  volume={6 3},
  pages={257-69}
}
Gonadotropin-Releasing Hormone (GnRH) is the hypothalamic decapeptide which plays a key role in the control of reproductive functions. By binding to specific receptors present on the pituitary gonadotropes, GnRH regulates gonadotropin release and, consequently, steroid hormone secretion from the gonads. When given continuously and at high doses, GnRH agonists suppress the pituitary gonadal axis through the down-regulation and desensitization of its own receptors. Based on this rationale… CONTINUE READING

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