Gonadotropin-induced superovulation drives ovarian surface epithelia proliferation in CD1 mice.

@article{Burdette2006GonadotropininducedSD,
  title={Gonadotropin-induced superovulation drives ovarian surface epithelia proliferation in CD1 mice.},
  author={Joanna E. Burdette and Sarah J. Kurley and Signe M. Kilen and Kelly E. Mayo and Teresa K. Woodruff},
  journal={Endocrinology},
  year={2006},
  volume={147 5},
  pages={2338-45}
}
The ovarian surface epithelium (OSE) is a monolayer of cells that surround the ovary and accommodate repeated tear and repair in response to ovulation. OSE cells are thought to be the progenitors of 90% of ovarian cancers. Currently, the total amount of proliferation of the OSE has not been reported in response to one ovulatory event. In this study, proliferation of the OSE was quantified in response to superovulation induced by ip injection of pregnant mare serum gonadotropin (PMSG) and human… CONTINUE READING

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