Gonadotrophin releasing hormone pulse generator activity before and during sexual maturation in girls: new insights.

@article{Yen1993GonadotrophinRH,
  title={Gonadotrophin releasing hormone pulse generator activity before and during sexual maturation in girls: new insights.},
  author={Samuel Yen and Dan Apter and T L B{\"u}tzow and Gail A. Laughlin},
  journal={Human reproduction},
  year={1993},
  volume={8 Suppl 2},
  pages={66-71}
}
The activity of the gonadotrophin releasing hormone (GnRH) pulse generator during pubertal transition was investigated in 40 healthy girls 7-18 years of age. Ten were pre-pubertal, seven were in early puberty, and 23 were post-menarcheal. Serum concentrations of luteinizing hormone (LH) and follicle stimulating hormone (FSH) were measured with immunofluorimetric assays, which have a sensitivity approximately 100-fold that of radioimmunoassay, in samples taken at 10-min intervals for 24 h during… CONTINUE READING