Gonadal steroids regulate GABAA receptor subunit mRNA expression in NT2-N neurons.

@article{Pierson2005GonadalSR,
  title={Gonadal steroids regulate GABAA receptor subunit mRNA expression in NT2-N neurons.},
  author={Rebecca C Pierson and Anne Marie Lyons and Lazar John Greenfield},
  journal={Brain research. Molecular brain research},
  year={2005},
  volume={138 2},
  pages={105-15}
}
Changes in gonadal steroid hormone levels during the menstrual cycle affect seizure frequency in women with catamenial epilepsy. Since GABA(A) receptors (GABARs) contribute to the prevention and termination of seizures by reducing neuronal excitability, we hypothesized that fluctuating gonadal steroid levels might affect GABAR subunit expression, which could alter inhibitory tone leading to increased seizure activity. To address this question in a simplified environment in vitro, we examined… CONTINUE READING
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