Gonadal steroids and humoral immunity

  title={Gonadal steroids and humoral immunity},
  author={Sanaz Sakiani and Nancy J Olsen and W J Kovacs},
  journal={Nature Reviews Endocrinology},
Humoral immune responses are sexually dimorphic. Female individuals generally exhibit more-robust antibody responses to vaccines and, in the clinical setting as well as in experimental models, are more likely than male individuals to produce autoreactive antibodies of pathogenic potential. A number of differences between the sexes might account for these observations, including differences in the dosage of specific X-chromosome and Y-chromosomal genes, increased exposure of female individuals… CONTINUE READING
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