Gonadal steroids and humoral immunity

@article{Sakiani2013GonadalSA,
  title={Gonadal steroids and humoral immunity},
  author={Sanaz Sakiani and Nancy J Olsen and W J Kovacs},
  journal={Nature Reviews Endocrinology},
  year={2013},
  volume={9},
  pages={56-62}
}
Humoral immune responses are sexually dimorphic. Female individuals generally exhibit more-robust antibody responses to vaccines and, in the clinical setting as well as in experimental models, are more likely than male individuals to produce autoreactive antibodies of pathogenic potential. A number of differences between the sexes might account for these observations, including differences in the dosage of specific X-chromosome and Y-chromosomal genes, increased exposure of female individuals… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 3 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 46 extracted citations

Alterations in nuclear structure promote lupus autoimmunity in a mouse model

Disease models & mechanisms • 2016
View 4 Excerpts
Highly Influenced

Sex Differences in HIV Infection

Current HIV/AIDS reports • 2018
View 2 Excerpts

References

Publications referenced by this paper.
Showing 1-10 of 67 references

Differential regulation of selfreactivity discriminates between IgG+ human circulating memory B cells and bone marrow plasma cells

Scheid, F J.
Proc. Natl Acad. Sci. USA 108, • 2011

modulation by HoxC4

White, C. A. et al. AID dysregulation in lupus-prone MRLFasl recombination, promotes interchromosomal c-MycIgH loci translocations
Autoimmunity 44, 585–598 • 2011

Similar Papers

Loading similar papers…