Gonadal steroid modulation of stress-induced hypothalamo-pituitary-adrenal activity and anxiety behavior: role of central oxytocin.

@article{Windle2006GonadalSM,
  title={Gonadal steroid modulation of stress-induced hypothalamo-pituitary-adrenal activity and anxiety behavior: role of central oxytocin.},
  author={Richard J. Windle and Lisa E Gamble and Yvonne M. Kershaw and Susan A. Wood and Stafford L. Lightman and Colin David Ingram},
  journal={Endocrinology},
  year={2006},
  volume={147 5},
  pages={2423-31}
}
Intracerebroventricular administration of oxytocin reduces anxiety behavior and hypothalamo-pituitary-adrenal (HPA) responses to stress in female rats. Similar changes are seen in late-pregnant rats, and oxytocin-sensitive pathways may mediate these effects. This study investigated anxiety behavior and stress responses using a gonadal steroid model of late pregnancy, which is known to increase endogenous oxytocin expression. Compared with continuous progesterone treatment, 3-d withdrawal of… CONTINUE READING
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