Gonadal steroid hormone modulation of nociception, morphine antinociception and reproductive indices in male and female rats

@article{Stoffel2003GonadalSH,
  title={Gonadal steroid hormone modulation of nociception, morphine antinociception and reproductive indices in male and female rats},
  author={Erin C Stoffel and Catherine Mary Ulibarri and Rebecca M Craft},
  journal={Pain},
  year={2003},
  volume={103},
  pages={285-302}
}
The purpose of this study was to examine how gonadal steroid hormones modulate basal nociception and morphine antinociception relative to regulating reproduction in the adult rat. Male and female Sprague-Dawley rats were either gonadectomized (GDX) or sham-gonadectomized (sham); GDX males were implanted subcutaneously with capsules containing testosterone (T), estradiol (E2), dihydrotestosterone (DHT), E2 and DHT, or nothing (0). GDX females received E2, T, or empty (0) capsules immediately… CONTINUE READING

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