Gonadal hormones down-regulate reactive gliosis and astrocyte proliferation after a penetrating brain injury.

@article{GarcaEstrada1993GonadalHD,
  title={Gonadal hormones down-regulate reactive gliosis and astrocyte proliferation after a penetrating brain injury.},
  author={Joaqu{\'i}n Garc{\'i}a-Estrada and Jos{\'e} Antonio Del R{\'i}o and S Luqu{\'i}n and Eduardo Soriano and Luis Miguel Garcia-Segura},
  journal={Brain research},
  year={1993},
  volume={628 1-2},
  pages={271-8}
}
Astrocytes are a target for gonadal steroids in the normal brain. The putative modulation by gonadal hormones of the astrocytic reaction to brain injury was assessed in this study. Male and female adult Wistar albino rats were gonadectomized and, one month later, their brains were lesioned by a longitudinal incision crossing the parietal cerebral cortex, the CA1 field of the dorsal hippocampus and the dentate gyrus. Males were injected either with testosterone (20 micrograms/rat) or vehicle… CONTINUE READING

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