Gonadal hormones affect spine synaptic density in the CA1 hippocampal subfield of male rats.

@article{Lrnth2003GonadalHA,
  title={Gonadal hormones affect spine synaptic density in the CA1 hippocampal subfield of male rats.},
  author={Csaba L{\'e}r{\'a}nth and Ors Petneh{\'a}zy and Neil J Maclusky},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 5},
  pages={1588-92}
}
The effects of androgen on the density of spine synapses on pyramidal neurons in the CA1 area of the hippocampus were studied in male rats. Gonadectomy (GDNX) had no significant effect on the number of CA1 pyramidal cells but reduced CA1 spine synapse density by almost 50% (to 0.468 +/- 0.018 spine synapses/microm(3)) compared with sham-operated controls (0.917 +/- 0.06 spine synapses/microm(3)). Treatment of GDNX rats with testosterone propionate (500 microg/d, s.c., 2 d) increased spine… CONTINUE READING
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