Gonadal dysfunction and fertility problems in cancer survivors

  title={Gonadal dysfunction and fertility problems in cancer survivors},
  author={Marianne Bryd{\o}y and Sophie D. Foss{\aa} and Olav Dahl and Trine Bj{\o}ro},
  journal={Acta Oncologica},
  pages={480 - 489}
Gonadal dysfunction and fertility problems are adverse effects of cancer treatment or may be associated with specific malignancies. This review focuses on these problems in the young cancer survivors, where methods of protecting or restoring endocrine function and fertility need to be considered. In females, treatment adverse effects can result in infertility, but premature ovarian failure (POF) is probably relevant for more female cancer survivors, affecting also those who do not wish post… 

Preservation of female fertility during cancer treatment

A medical approach using the gonadotropin-releasing hormone analog (GnRHa) may act to protect the gonads during radiation and/or chemotherapy by preferentially steering cells into cell cycle arrest with a decline in responsibility to the chemotherapeutic agents.

Fertility Preservation in Gynecological Cancers

It is advocated that attention to long term health and quality of life in gonadotoxic therapy must be incorporated into plans as early as possible.

Fertility Preservation Options for Cancer Patients

Different options currently available to preserve fertility in men, women and adolescent children diagnosed with cancer and undergoing gonadotoxic therapy are presented.

Ovarian Function in Female Survivors of Childhood Malignancies

Female survivors of childhood malignancies had reduced ovarian reserve and reduced mean ovarian volume, especially those with older age, older age of menarche, and longer treatment duration.

Fertility considerations and preservation in haemato‐oncology patients undergoing treatment

The improved survival rates among patients with haematological malignancies, such as lymphoma and leukaemia, are shifting areas of focus towards understanding and preventing treatment‐induced sequelae, especially as pre‐pubertal patients present a unique constellation of fertility considerations.

Hypogonadism After Childhood Cancer Treatment

In a study of 2283 long-term survivors of childhood cancer Byrne and colleagues found that RT below the diaphragm depressed fertility in both sexes for about 25%, ChT with alkylating agents (AA) with or without RT belowThe diaphagm depressed infertility in men, in women, however, AA therapy administered alone had no apparent effect on fertility.

Cancer and fertility: strategies to preserve fertility.

Female reproductive health after childhood, adolescent, and young adult cancers: guidelines for the assessment and management of female reproductive complications.

  • M. MetzgerL. Meacham D. Green
  • Medicine
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2013
This review summarizes the current task force recommendations for the assessment and management of female reproductive complications after treatment for childhood, adolescent, and young adult cancers and discusses experimental pretreatment as well as post-treatment fertility preservation strategies.



Male fertility following childhood cancer: current concepts and future therapies.

In addition to the many scientific and technical issues to be overcome prior to clinical application of these techniques, a number of ethical and legal issues must also be addressed to ensure a safe and realistic prospect for future fertility in these patients.

The effects of cancer and cancer treatments on male reproductive function

In male cancer patients, surgery, radiotherapy and chemotherapy can be followed by transient or permanent infertility by affecting ejaculatory or erectile function, or by impairing spermatogenesis, and fertility-preserving measures before and during treatment should be considered.

Fertility, gonadal and sexual function in survivors of testicular cancer

Gonadal dysfunction is common in patients with a history of testicular cancer even when managed by orchidectomy alone and treatment with chemotherapy in particular can result in additional impairment.

Radiation damage to the uterus — Review of the effects of treatment of childhood cancer

It has been demonstrated that, in women treated with total body irradiation, sex steroid replacement in physiological doses significantly increases uterine volume and endometrial thickness, as well as re-establishing uterine blood flow, however, it is not known whether standard regimens of oestrogen replacement therapy are sufficient to facilitate uterine growth in adolescent women treated in childhood.

Fertility preservation in young women undergoing breast cancer therapy.

When and if a breast cancer patient does not have time to undergo ovarian stimulation prior to chemotherapy, ovarian cryopreservation for future autotransplantation can be offered as the last resort.

Treatment options for the infertile male with cancer.

Advances in assisted reproductive techniques allow in vitro fertilization to occur with the injection of a single sperm into an egg (IVF-ICSI), consequently, the requirement for the amount of sperm needed from cryopreservation is minimal and spermatogonial cell transplantation offer the potential to restore fertility in patients who have received radiation or chemotherapy.

Fertility of long‐term male survivors of acute lymphoblastic leukemia diagnosed during childhood

In this first study of proven fertility among men treated for childhood leukemia, the majority of survivors showed no evidence of fertility impairment compared to controls, however, men treated at a young age with high dose cranial RT may have impaired fertility.

Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects

Existing evidence supporting a new concept that poor semen quality, testis cancer, undescended testis and hypospadias are symptoms of one underlying entity, the testicular dysgenesis syndrome (TDS), which may be increasingly common due to adverse environmental influences is summarized.

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  • U. RuefferK. Breuer V. Diehl
  • Medicine, Biology
    Annals of oncology : official journal of the European Society for Medical Oncology
  • 2001
Assuming HD is the major initial cause for infertility efforts should be made to identify new non-gonadal toxic chemotherapies to be able to regain fertility after effective therapy.

The impact of cancer therapy on the endocrine system in survivors of childhood brain tumours.

Endocrine problems are very common in patients following cancer therapy for childhood brain tumours and the recognition and prompt management of these are essential to prevent further morbidity and impairment of quality of life.