Gonadal defects in Cited2-mutant mice indicate a role for SF1 in both testis and ovary differentiation.

@article{Combes2010GonadalDI,
  title={Gonadal defects in Cited2-mutant mice indicate a role for SF1 in both testis and ovary differentiation.},
  author={Alexander N Combes and Cassy M Spiller and Vincent R Harley and Andrew H. Sinclair and Sally L. Dunwoodie and Dagmar Wilhelm and Peter Koopman},
  journal={The International journal of developmental biology},
  year={2010},
  volume={54 4},
  pages={683-9}
}
Sex determination is regulated by a molecular antagonism between testis- and ovary-determining pathways in the supporting cell lineage of the gonadal primordia. Genes important for maintaining this lineage play critical roles in early gonadal development, but their influence on testis and ovary differentiation is unclear due to the severity of loss-of-function phenotypes. The transcription factor SF1 (Nr5a1/Ad4BP) is one such factor, required for establishing the supporting cell lineage, and… CONTINUE READING

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is initiated by Cited 2 and Wt 1 through modulation of Sf1 dosage

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