Gonadal Asymmetry and Sex Determination in Birds

@article{Guioli2014GonadalAA,
  title={Gonadal Asymmetry and Sex Determination in Birds},
  author={Silvana Guioli and Sunil Nandi and Debiao Zhao and Jessica Burgess-Shannon and Robin Lovell-Badge and Michael Clinton},
  journal={Sexual Development},
  year={2014},
  volume={8},
  pages={227 - 242}
}
Although vertebrates display a superficial bilateral symmetry, most internal organs develop and locate with a consistent left:right asymmetry. There is still considerable debate as to when this process actually begins, but it seems that, at least for some species, the initial steps occur at a very early stage of development. In recent years, a number of model systems, including the chick embryo, have been utilised to increase our understanding of the molecular basis of this complex… Expand
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References

SHOWING 1-10 OF 146 REFERENCES
PITX2 controls asymmetric gonadal development in both sexes of the chick and can rescue the degeneration of the right ovary
TLDR
It is shown that the chick gonads already have distinct morphological and molecular left-right (L-R) characteristics in both sexes at indifferent (genital ridge) stages and that these persist, becoming more elaborate during sex determination and differentiation, but have no consequences for testis differentiation. Expand
Mechanism of asymmetric ovarian development in chick embryos
TLDR
It is suggested that early asymmetric expression of PITX2 leads to asymmetric ovarian development through up- or downregulation of RALDH2, Ad4BP/SF-1, estrogen receptor α and cyclin D1. Expand
Sexually Dimorphic and Sex-Independent Left-Right Asymmetries in Chicken Embryonic Gonads
TLDR
Germ cell and pluripotency-associated genes show both sex-dependent and independent left-right asymmetry and a complex pattern of expression in both sexes. Expand
Left–right asymmetry in embryonic development: a comprehensive review
  • M. Levin
  • Medicine, Biology
  • Mechanisms of Development
  • 2005
TLDR
This review summarizes the current knowledge regarding LR patterning in a number of vertebrate and invertebrate species, discusses several poorly understood but important phenomena, and highlights some important open questions about the evolutionary origin and conservation of mechanisms underlying embryonic asymmetry. Expand
Pitx2 regulates gonad morphogenesis
TLDR
Observations indicate that the effects elicited by Pitx2 during the development of the female chick ovary are critical for cell topology, growth, fate, and ultimately organ morphogenesis and function. Expand
The Molecular Genetics of Ovarian Differentiation in the Avian Model
TLDR
This review discusses sexual differentiation in chicken embryos, with emphasis on ovarian development, and highlights genes that may play a conserved role in this process, and discusses how interaction between ovarian pathways may be regulated. Expand
Somatic sex identity is cell-autonomous in the chicken
TLDR
This study demonstrates that avian somatic cells possess an inherent sex identity and that, in birds, sexual differentiation is substantively cell autonomous and that the sex-determining mechanism in birds is investigated. Expand
Mechanisms of gonadal morphogenesis are not conserved between chick and mouse.
TLDR
This is the first demonstration via lineage analysis that steroidogenic cells originate from nephrogenous mesenchyme, but the revelation that Sertoli cells have different origins between chick and mouse suggests that, during evolution, mechanisms of gonad morphogenesis may diverge alongside those of sex determination. Expand
A unified model for left-right asymmetry? Comparison and synthesis of molecular models of embryonic laterality.
TLDR
Experimental data are examined that lend strong support to an early origin of LR asymmetry, yet are also consistent with later roles for cilia in the amplification of LR pathways, and an alternative hypothesis is presented which proposes that individual embryos stochastically choose one of several possible pathways with which to establish their LR axis. Expand
Retinoic acid coordinates somitogenesis and left–right patterning in vertebrate embryos
TLDR
It is reported that blocking the production of retinoic acid in chicken embryos leads to a desynchronization of somite formation between the two embryonic sides, demonstrated by a shortened left segmented region. Expand
...
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3
4
5
...