Gonadal, adrenal, and neuroactive steroids' role in ictal activity

  title={Gonadal, adrenal, and neuroactive steroids' role in ictal activity},
  author={Madeline E. Rhodes and Jacob P. Harney and Cheryl Anne Frye},
  journal={Brain Research},
Of the many people that have epilepsy, only about 70% achieve seizure control with traditional pharmacotherapies. Steroids have long been known to influence ictal activity and may have a therapeutic role. This review summarizes recent investigations that have enhanced knowledge of the effects and mechanisms of gonadal, adrenal, and neuroactive steroids on seizure processes. Progesterone, which varies across reproductive cycles, pregnancy, and as a function of aging, has been shown to have anti… CONTINUE READING


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