Gonad-stimulating substance-like molecule from the radial nerve of the sea cucumber.

  title={Gonad-stimulating substance-like molecule from the radial nerve of the sea cucumber.},
  author={Hideki Katow and Tomoko Katow and Akihiko Moriyama},
  journal={The International journal of developmental biology},
  volume={53 4},
Gonad-stimulating substance-like molecule (GSSL) was isolated from the radial nerve of the sea cucumber, Apostichopus japonicus (Aj-GSSL), and its partial DNA and protein sequences were characterized. The smaller part of the molecule that also retains GSSL activity was estimated. Radial nerve extract (RNE) induced germinal vesicle breakdown (GVBD) at 3 mg/ml in 85% of immature ovarian oocytes. Similar intensity of GSSL activity to RNE was seen in a fraction that contained peptides between 3 kDa… CONTINUE READING


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