Golgin-84-associated Golgi fragmentation triggers tau hyperphosphorylation by activation of cyclin-dependent kinase-5 and extracellular signal-regulated kinase.

@article{Jiang2014Golgin84associatedGF,
  title={Golgin-84-associated Golgi fragmentation triggers tau hyperphosphorylation by activation of cyclin-dependent kinase-5 and extracellular signal-regulated kinase.},
  author={Qian Jiang and Lu Wang and Yang Tai Guan and Hui Xu and Yi Wen Niu and Li Han and Yu-Ping Wei and Li Lin and Jiang Chu and Qun Wang and Ying Yang and Lei Pei and J Wang and Q. I. Tian},
  journal={Neurobiology of aging},
  year={2014},
  volume={35 6},
  pages={1352-63}
}
Tau hyperphosphorylation is a critical event in Alzheimer's disease, in which the neuronal Golgi fragmentation occurs earlier than tau hyperphosphorylation. However, the intrinsic link between Golgi impairment and tau pathology is missing. By electron microscopy and western blotting, we observed in the present study that the neuronal Golgi fragmentation was increased age-dependently with a correlated tau hyperphosphorylation in the brains of C57BL/6 mice aged from 4 to 16 months. Simultaneously… CONTINUE READING