Golgi in copper homeostasis: a view from the membrane trafficking field

  title={Golgi in copper homeostasis: a view from the membrane trafficking field},
  author={Roman Polishchuk and Svetlana Lutsenko},
  journal={Histochemistry and Cell Biology},
Copper is essential for a variety of important biological processes as a cofactor and regulator of many enzymes. Incorporation of copper into the secreted and plasma membrane-targeted cuproenzymes takes place in Golgi, a compartment central for normal copper homeostasis. The Golgi complex harbors copper-transporting ATPases, ATP7A and ATP7B that transfer copper from the cytosol into Golgi lumen for incorporation into copper-dependent enzymes. The Golgi complex also sends these ATPases to… CONTINUE READING


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