Golgi defects enhance APP amyloidogenic processing in Alzheimer's disease.

  title={Golgi defects enhance APP amyloidogenic processing in Alzheimer's disease.},
  author={Gunjan Joshi and Yanzhuang Wang},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={37 3},
Increased amyloid beta (Aβ) production by sequential cleavage of the amyloid precursor protein (APP) by the β- and γ-secretases contributes to the etiological basis of Alzheimer's disease (AD). This process requires APP and the secretases to be in the same subcellular compartments, such as the endosomes. Since all membrane organelles in the endomembrane system are kinetically and functionally linked, any defects in the trafficking and sorting machinery would be expected to change the functional… CONTINUE READING

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