Golgi and plasma membrane pools of PI(4)P contribute to plasma membrane PI(4,5)P2 and maintenance of KCNQ2/3 ion channel current.

Abstract

Plasma membrane (PM) phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] regulates the activity of many ion channels and other membrane-associated proteins. To determine precursor sources of the PM PI(4,5)P2 pool in tsA-201 cells, we monitored KCNQ2/3 channel currents and translocation of PHPLCδ1 domains as real-time indicators of PM PI(4,5)P2, and… (More)
DOI: 10.1073/pnas.1407133111

Topics

9 Figures and Tables

Cite this paper

@article{Dickson2014GolgiAP, title={Golgi and plasma membrane pools of PI(4)P contribute to plasma membrane PI(4,5)P2 and maintenance of KCNQ2/3 ion channel current.}, author={Eamonn J. Dickson and Jill B. Jensen and Bertil Hille}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2014}, volume={111 22}, pages={E2281-90} }