Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P

@article{Xu2006GolgiAC,
  title={Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P},
  author={Ruijuan Xu and Junfei Jin and Wei Hu and Wei Sun and Jacek Bielawski and Zdzislaw M. Szulc and Tarek A Taha and Lina M. Obeid and Cungui Mao},
  journal={The FASEB Journal},
  year={2006},
  volume={20},
  pages={1813 - 1825}
}
Sphingosine‐1‐phosphate (S1P), a sphingolipid metabolite, promotes cell proliferation and survival whereas its precursor, sphingosine, has the opposite effects. However, much remains unknown about their regulation. Here we identify a novel human ceramidase (haCER2) that regulates the levels of both sphingosine and S1P by controlling the hydrolysis of ceramides. haCER2 is localized to the Golgi complex and is highly expressed in the placenta. High ectopic expression of haCER2 caused… 
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