Golgi Tubule Traffic and the Effects of Brefeldin A Visualized in Living Cells

@article{Sciaky1997GolgiTT,
  title={Golgi Tubule Traffic and the Effects of Brefeldin A Visualized in Living Cells },
  author={Noah Sciaky and John F. Presley and Carolyn L. Smith and Kristien J Zaal and Nelson B. Cole and Jorge E. Moreira and Mark Terasaki and Eric D. Siggia and Jennifer Lippincott-Schwartz},
  journal={The Journal of Cell Biology},
  year={1997},
  volume={139},
  pages={1137 - 1155}
}
The Golgi complex is a dynamic organelle engaged in both secretory and retrograde membrane traffic. Here, we use green fluorescent protein-Golgi protein chimeras to study Golgi morphology in vivo. In untreated cells, membrane tubules were a ubiquitous, prominent feature of the Golgi complex, serving both to interconnect adjacent Golgi elements and to carry membrane outward along microtubules after detaching from stable Golgi structures. Brefeldin A treatment, which reversibly disassembles the… CONTINUE READING
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