Golgi Tubule Traffic and the Effects of Brefeldin A Visualized in Living Cells

  title={Golgi Tubule Traffic and the Effects of Brefeldin A Visualized in Living Cells },
  author={Noah Sciaky and John F. Presley and Carolyn L. Smith and Kristien J Zaal and Nelson B. Cole and Jorge E. Moreira and Mark Terasaki and Eric D. Siggia and Jennifer Lippincott-Schwartz},
  journal={The Journal of Cell Biology},
  pages={1137 - 1155}
The Golgi complex is a dynamic organelle engaged in both secretory and retrograde membrane traffic. Here, we use green fluorescent protein-Golgi protein chimeras to study Golgi morphology in vivo. In untreated cells, membrane tubules were a ubiquitous, prominent feature of the Golgi complex, serving both to interconnect adjacent Golgi elements and to carry membrane outward along microtubules after detaching from stable Golgi structures. Brefeldin A treatment, which reversibly disassembles the… CONTINUE READING
Highly Influential
This paper has highly influenced 14 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Highly Cited
This paper has 255 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 147 extracted citations

Localization of myocilin to the golgi apparatus in Schlemm's canal cells.

Investigative ophthalmology & visual science • 2000
View 4 Excerpts
Highly Influenced

255 Citations

Citations per Year
Semantic Scholar estimates that this publication has 255 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 78 references

Physiochemical Hydrodynamics

R. F. Probstein
Second Edition. John Wiley and Sons, New York. 338–357. • 1994
View 5 Excerpts
Highly Influenced

Recycling of proteins between the endoplasmic reticulum and Golgi complex.

Current opinion in cell biology • 1991
View 4 Excerpts
Highly Influenced

Three-dimensional electron microscopy: structure of the Golgi apparatus.

European journal of cell biology • 1990
View 4 Excerpts
Highly Influenced