Gold-resistant bacteria: excretion of a cystine-rich protein by Pseudomonas cepacia induced by an antiarthritic drug.

@article{Higham1986GoldresistantBE,
  title={Gold-resistant bacteria: excretion of a cystine-rich protein by Pseudomonas cepacia induced by an antiarthritic drug.},
  author={D P Higham and Peter J Sadler and Michael D. Scawen},
  journal={Journal of inorganic biochemistry},
  year={1986},
  volume={28 2-3},
  pages={253-61}
}
P. cepacia bacteria adapted to growth in a chemically defined medium containing millimolar concentrations of Au(I) thiolates including the antiarthritic drug Au(I) thiomalate. The bacteria became very large, accumulated polyhydroxybutyrate and gold, and excreted a yellow protein ("thiorin"), which caused foaming of the culture medium. Thiorin was shown by 1H-NMR, amino acid analysis, and gel filtration chromatography to be of low molecular weight (ca. 9500) and to contain predominantly Cys… CONTINUE READING

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