Gold nanorod--siRNA induces efficient in vivo gene silencing in the rat hippocampus.

Abstract

AIM Gold nanorods (GNRs), cellular imaging nanoprobes, have been used for drug delivery therapy to immunologically privileged regions in the brain. We demonstrate that nanoplexes formed by electrostatic binding between negatively charged RNA and positively charged GNRs, silence the expression of the target housekeeping gene, glyceraldehyde 3-phosphate… (More)
DOI: 10.2217/nnm.11.20

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Cite this paper

@article{Bonoiu2011GoldNI, title={Gold nanorod--siRNA induces efficient in vivo gene silencing in the rat hippocampus.}, author={Adela C Bonoiu and Earl J. Bergey and Hong Ding and Rui Hu and Rajiv Kumar and Ken-Tye Yong and Paras N. Prasad and Supriya D. Mahajan and Kelly E. Picchione and Arin Bhattacharjee and Tracey A. Ignatowski}, journal={Nanomedicine}, year={2011}, volume={6 4}, pages={617-30} }