Gold nanoparticles disrupt zebrafish eye development and pigmentation.

  title={Gold nanoparticles disrupt zebrafish eye development and pigmentation.},
  author={Ki-Tae Kim and Tatiana O. Zaikova and James E Hutchison and Robert L. Tanguay},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  volume={133 2},
Systematic toxicological study is still required to fully understand the hazard potentials of gold nanoparticles (AuNPs). Because their biomedical applications are rapidly evolving, we investigated developmental toxicity of AuNPs in an in vivo embryonic zebrafish model at exposure concentration ranges from 0.08 to 50mg/l. Exposure of zebrafish embryos to 1.3 nm AuNPs functionalized with a cationic ligand, N,N,N-trimethylammoniumethanethiol (TMAT-AuNPs), resulted in smaller malpigmented eyes. We… CONTINUE READING
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