• Medicine
  • Published in
    Journal of gastrointestinal…
    2012

Gold nanoparticles conjugated with cisplatin/doxorubicin/capecitabine lower the chemoresistance of hepatocellular carcinoma-derived cancer cells.

@article{Tomuleasa2012GoldNC,
  title={Gold nanoparticles conjugated with cisplatin/doxorubicin/capecitabine lower the chemoresistance of hepatocellular carcinoma-derived cancer cells.},
  author={Ciprian Tomuleasa and Olga Soriţău and Anamaria Orza and Mircea Dudea and Bobe Petrushev and Ofelia Moşteanu and Sergiu Șușman and Adrian Florea and Emőke P{\'a}ll and Mihaela Aldea and Gabriel Kacs{\'o} and Victor Cristea and Ioana Berindan-Neagoe and Alexandru Irimie},
  journal={Journal of gastrointestinal and liver diseases : JGLD},
  year={2012},
  volume={21 2},
  pages={
          187-96
        }
}
BACKGROUND AND AIMS The aim of the current study was to evaluate in vitro the anti-tumor efficacy of gold nanoparticles (GNPs) conjugated with conventional chemotherapy drugs for the treatment of liver cancer. This approach based on gold proposes a novel platform therapy with minimal toxicity and increased efficacy profiles for the destruction of hepatic cancer cells. METHODS GNPs, stabilized with a monolayer of L-aspartate and additional cytostatic drugs, were successfully used as a complex… CONTINUE READING

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