Gold-nanoparticles coated with the antimicrobial peptide esculentin-1a(1-21)NH2 as a reliable strategy for antipseudomonal drugs.

@article{Casciaro2017GoldnanoparticlesCW,
  title={Gold-nanoparticles coated with the antimicrobial peptide esculentin-1a(1-21)NH2 as a reliable strategy for antipseudomonal drugs.},
  author={Bruno Casciaro and Mar{\'i}a Lapresta Moros and Sara Rivera-Fern{\'a}ndez and Andrea Bellelli and Jes{\'u}s Mart{\'i}nez de la Fuente and Maria Luisa Mangoni},
  journal={Acta biomaterialia},
  year={2017},
  volume={47},
  pages={170-181}
}
Naturally occurring antimicrobial peptides (AMPs) hold promise as future therapeutics against multidrug resistant microorganisms. Recently, we have discovered that a derivative of the frog skin AMP esculentin-1a, Esc(1-21), is highly potent against both free living and biofilm forms of the bacterial pathogen Pseudomonas aeruginosa. However, bringing AMPs into clinics requires to overcome their low stability, high toxicity and inefficient delivery to the target site at high concentrations… CONTINUE READING
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