Gold nanoparticles-based nanoconjugates for enhanced enzyme cascade and glucose sensing.

@article{Zeng2012GoldNN,
  title={Gold nanoparticles-based nanoconjugates for enhanced enzyme cascade and glucose sensing.},
  author={Dongdong Zeng and Weijie Luo and Jiang Li and Huajie Liu and Hongwei Ma and Qing Huang and Chunhai Fan},
  journal={The Analyst},
  year={2012},
  volume={137 19},
  pages={
          4435-9
        }
}
We have coupled gold nanoparticles with horseradish peroxidase (HRP) to assemble catalytic nanoconjugates (HRP-AuNPs) for glucose detection. We found that a proper mixing ratio of HRP/AuNPs can significantly improve catalytic activity for the cascade reaction, an effect arising from increased spatial coupling between enzymes. Such gold nanoparticle-based nanoconjugates are shown to be promising nanosensors for glucose. 
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