Gold nanoparticle-based homogeneous fluorescent aptasensor for multiplex detection.

Abstract

We developed a homogeneous fluorescence assay for multiplex detection based on the target induced conformational change of DNA aptamers. DNA aptamers were immobilized on quantum dots (QDs), and QDs conjugated ssDNA was adsorbed on the surface of gold nanoparticles (AuNPs) by electrostatic interaction between uncoiled ssDNA and the AuNPs. Subsequently the… (More)
DOI: 10.1039/c1an15261k

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