Gold-catalyzed cascade cyclization of (azido)ynamides: an efficient strategy for the construction of indoloquinolines.

Abstract

(Azido)ynamides were efficiently converted into indoloquinolines by the use of a gold catalyst. While ynamides bearing an allylsilane gave terminal alkenes, ynamides bearing a simple alkene gave cyclopropanes. This reaction proceeds through the formation of an α-amidino gold carbenoid.

DOI: 10.1021/ol5012604

Cite this paper

@article{Tokimizu2014GoldcatalyzedCC, title={Gold-catalyzed cascade cyclization of (azido)ynamides: an efficient strategy for the construction of indoloquinolines.}, author={Yusuke Tokimizu and Shinya Oishi and Nobutaka Fujii and Hiroaki Ohno}, journal={Organic letters}, year={2014}, volume={16 11}, pages={3138-41} }